Fig. 4: Defense response genes are upregulated in col-99(gk694263[S106L]) SNP mutants. | npj Aging

Fig. 4: Defense response genes are upregulated in col-99(gk694263[S106L]) SNP mutants.

From: A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans

Fig. 4

a Logarithmic scale representing the distribution of differentially expressed genes in col-99(gk694263[S106L]) SNP mutant versus wild-type. b The graph shows an increase in the expression of col-99 transcripts in col-99(gk694263[S106L]) SNP mutant compared to wild-type (in terms of FKPM values). c GO term analysis showing downregulated and upregulated genes in col-99(gk694263[S106L]) SNP mutant to wild-type. RNA sequencing was performed with three biological batches. d Targeted screening to find regulators of T24B8.5 GFP expression. Data is plotted as mean, and error bars represent SEM. Two-tailed Welch’s t-test statistical analysis. The experiment was performed in three biological batches. col-99(SNP) is col-99(gk694263[S106L]).

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