Fig. 1: Overview of theoretical and computational framework.
From: The dissipation theory of aging: a quantitative analysis using a cellular aging map
a Decomposition of aging manifold in time using Hopf decomposition into conservative and dissipative components (b) aggregation of 1528 single-cell RNA-seq dataset encompassing various age groups, tissues, and cell types, (c) modeling of gene expression using a transformer-based model with metadata information and age token, (d) cellular aging map constructed from the output embedding of the model (Created in https://BioRender.com).
