Fig. 5 | npj Biofilms and Microbiomes

Fig. 5

From: Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility

Fig. 5

Proposed mechanism for e-scaffold generated H2O2 enhancing antibiotic susceptibility. H2O2 generated extracellularly by e-scaffold diffuses through the bacterial cell envelope and reacts with intracellular Fe2+, forming radicals that oxidize lipids, proteins and DNA, which prompts cell death. Through membrane damage or changing membrane permeability, antibiotic penetration into the bacterial cell is increased, which in turn enhances the antibiotic susceptibility of the cells

Back to article page