Fig. 2
From: Designed α-sheet peptides suppress amyloid formation in Staphylococcus aureus biofilms
S. aureus biofilm structures become less robust when grown in the presence of designed peptide inhibitors. a S. aureus MN8 + mCherry biofilms were grown on glass substrates for 24 h and then cells were washed and fixed. The peptide inhibitors (80 μM) caused cells to detach during the wash step. Images are representative of triplicate wells. For quantification of the images see Supplementary Fig. S2. b In S. aureus SH1000 WT biofilms grown in regular LB medium, PSM amyloid fibrils were visible as deposits in spaces between cells (left). Upon addition of the designed peptide AP90 (80 μM), no extracellular fibril deposits were observed (right)
