Table 1 Activity of the lantibiotic group of bacteriocins against biofilms
From: Fighting biofilms with lantibiotics and other groups of bacteriocins
Bacteriocin(s) | Biofilm former | Effects | Reference |
|---|---|---|---|
Nisin in combination with antibiotics | MRSA | Nisin-antibiotic combinations prevented biofilm formation | |
Nisin with ciprofloxacin/daptomycin | MRSA | Synergy between nisin and ciprofloxacin/daptomycin against biofilm | |
Nisin, lacticin Q, nukacin ISK-1 | MRSA | Nisin and lacticin Q potent against biofilm, causing pore formation, efflux of ATP from biofilm. No anti-biofilm activity for nukacin ISK-1 | |
Nisin, bovicin HC5 | S. aureus | Reduced adhesion to polystyrene. Reduced expression of genes involved in biofilm formation | |
Nisin and lysozyme | 25 S. aureus strains | 1× MIC nisin prevented biofilm formation | |
Gallidermin | S. aureus, S. epidermidis | Prevention of biofilm formation. Persister cells survived | |
Nisin | S. epidermidis | Loss of green fluorescence from biofilm, loss of viability and membrane integrity | |
Nisin I4V | S. pseudintermedius | I4V inhibited formation and reduced biomass of biofilms | |
Nisin I4V | S. pseudintermedius | I4V potent against DSM21284 biofilms | |
Nisin M21A with citric acid or cinnamaldehyde | L. monocytogenes F2635 | Nisin combined with essential oils effective against biofilm | |
Nisin | L. monocytogenes 4032 | Mature biofilms on stainless steel and polypropylene recalcitrant to nisin | |
Nisin | S. aureus, L. monocytogenes, Salmonella enteritidis | 4000 IU/ml particularly effective against Salmonella enteritidis and L. monocytogenes biofilm formation | |
Nisin at low pH with high hydrostatic pressure (HHP) | L. monocytogenes | Nisin at low pH combined with HHP effective against biofilms | |
Nisin and polymyxin | P. aeruginosa | Inhibition of biofilm formation. Dose of polymyxin required lowered | |
Nisin in combination with Glu, Asp, Cys | Strep. mutans | Improved potency against Strep. mutans biofilms with nisin-amino acid combinations | |
Nisin | Strep. mutans 10449 | Inhibition of glucan biofilm synthesis. Encapsulated nisin most effective | |
Nisin | Oral biofilm | Loss of green fluorescence across biofilm cell clusters | |
Lacticin 3147 | Strep. mutans | 2× MIC disrupted formation of biofilms. Ineffective against 4-h-old biofilms | |
Nisin and MTAD | E. faecalis | Nisin and doxycycline inhibited E. faecalis biofilms | |
NisinZP and sodium hypochlorite | E. faecalis | Thickness and bio-volume of biofilm decreased | |
Nisin and MTAD | E. faecalis, A. viscosus | No effect on biofilms | |
Subtilomycin, lichenicidin and nisinZ | L. monocytogenes | Prevention of biofilm formation | |
EntV | C. albicans | Prevention of C. albicans biofilm formation |
