Table 1 Mixed model analysis of relative abundance of bacterial taxa

From: Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron

  

Fixed effects

Taxonomic rank

Denomination

Diet

Treatment

Def

Sup

IV iron

Transfusion

Phylum

Proteobacteria

3.91**

−2.25

−2.41*

−2.98*

Class

Bacilli

5.97***

−4.54*

−6.98***

−3.84*

Clostridia

−8.16***

2.54

10.73****

9.19****

Betaproteobacteria

2.63***

−0.9

−0.36

−0.88

Order

Lactobacillales

6.02***

−4.65*

−7.24****

−4.18*

Clostridiales

−7.72***

2.97

10.46****

9.03****

Burkholderiales

2.63***

−0.9

−0.36

−0.88

Family

Lachnospiraceae

−4.12****

0.67

0.51

0.22

Streptococcaceae

0.26**

−0.23*

−0.36****

−0.19*

Peptococcaceae

−1.41

2.45**

3.45****

2.25**

Clostridiaceae

−1.77**

2.39**

2.81****

2.44***

Lactobacillaceae

5.76***

−4.42*

−6.89***

−3.99*

Genus

Parabacteroides

4.56****

−1.80*

−3.76****

−2.96**

Ruminococcus

−0.14

1.32****

0.14

0.04

Lactobacillus

5.76***

−4.42*

−6.89***

−3.99*

Dehalobacterium

−0.04

0.12

0.30***

0.34****

Species

Bacteroides acidifaciens

−3.17****

−1.18

0.04

1.46*

Parabacteroides distasonis

2.14**

−1.07

−1.29*

−1.14

  1. Parameter estimates of taxa modulated by dietary iron, intravenous (IV) iron, or chronic transfusion with a p value < 0.0001 for the test of fixed effects. Positive and negative values indicate increasing and decreasing trend, respectively, when compared with cohorts of mice fed an iron-replete diet alone. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001