Fig. 4: Upregulated genes in biofilm growth in comparison to planktonic growth.
From: Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype
a The Venn diagram depicts commonly upregulated genes (70 genes) among all three biofilm clusters as well as cluster-specific regulated genes (A: 388; B: 33; C: 85 genes). b The GO term enrichment analysis of upregulated genes shows biological functions that are exclusively regulated in a certain biofilm cluster or shared by two or all three structural groups. The red color gradient represents the value of the enrichment factor. c A significant higher pyoverdine production was observed in biofilms (48 h) compared to planktonic cultures (24 h), as shown exemplarily for 33 clinical isolates. d Pyoverdine production in biofilm cultures was enhanced in all three biofilm clusters, independent of structural characteristics. Statistical significance was calculated with the Student’s t test and is displayed as *p < 0.05. Each datapoint represents one individual clinical isolate. Error bars represent the standard deviation.
