Fig. 2: Association of abundant OTUs with pre-debridement wound samples or skin samples, inferred by DESeq2 or BGLMM. | npj Biofilms and Microbiomes

Fig. 2: Association of abundant OTUs with pre-debridement wound samples or skin samples, inferred by DESeq2 or BGLMM.

From: Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds

Fig. 2

OTUs (with average relative abundance > 0.1%) found to be significant (criteria described in Methods) in at least one of the models with enrichment in wound samples (red) or enrichment in skin samples (blue). OTUs found to be not significantly enriched in that model are shown as gray. For DESeq2, the log2 fold-change in variance-stabilized abundance is shown with error bars indicating the estimated 95% confidence interval (1.96× standard error, n = 19). For BGLMM, the median of estimated \(\beta _{j1}\) (pre-debridement effect for OTU \(j\), see Methods for details) with 95% credible interval error bars are reported (n = 19). The heatmap shows the log10 (relative abundance in wound minus relative abundance in skin) of each OTU of each patient for a visual comparison. OTUs are labeled by their genus name or lowest available taxonomy assignment if applicable; otherwise, the original OTU label from QIIME open OTU picking is used. Note that multiple OTUs may belong to the same genus.

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