Table 3 Summary of the most significant hallmark host responses in patients with PEDIS 4 when compared to PEDIS 3.
NAME | Process category | Description | NES | FWER |
|---|---|---|---|---|
Enriched host pathways in PEDIS 4 | ||||
TNFA_SIGNALING_VIA_NFKB (TNF-alpha/nuclear factor kappa-light-chain-enhancer of activated B cells) | Signaling | Genes regulated by NF-kB in response to TNF | 1.9023656 | 0 |
IL6_JAK_STAT3_SIGNALING (Interleukin 6/Janus kinase/signal transducers and activators for transcription | Signaling | Genes upregulated by IL6 via STAT3 e.g., during acute phase response | 1.7342762 | 0 |
INFLAMMATORY_RESPONSE | Immune | Genes defining inflammatory response | 1.6779492 | 0 |
PI3K_AKT_MTOR_SIGNALING (Phosphatidylinositide 3 kinases/Protein kinase B/mammalian target of rapamycin. | Signaling | Genes upregulated by activation of the PI3K/AKT/mTOR pathway, regulating cell proliferation, survival, and metabolism | 1.6093148 | 0.00 |
HYPOXIA | Pathway | Genes upregulated in response to low oxygen levels | 1.5994961 | 0.00 |
REACTIVE_OXIGEN_SPECIES | Pathway | Genes upregulated by reactive oxygen species (ROS) | 1.578071 | 0.00 |
UV_RESPONSE | DNA damage | Genes upregulated in response to ultraviolet (UV) radiation | 1.5617301 | 0.01 |
APOPTOSIS | Pathway | Genes mediating programmed cell death by activation of caspases | 1.5393971 | 0.01 |
IL2_STAT5_SIGNALING (Interleukin 2/signal transducers and activators for transcription) | Signaling | Genes upregulated by STAT5 in response to IL2 stimulation | 1.5364993 | 0.02 |
HEME_METABOLISM | Metabolic | Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation | 1.534089 | 0.02 |
HALLMARK_P53_PATHWAY (Tumor protein 53) | Proliferation | Genes involved in p53 pathways and networks in response to stress signals that impact upon cellular homeostatic mechanisms that monitor DNA replication, chromosome segregation, and cell division | 1.5275651 | 0.02 |
ALLOGRAFT_REJECTION | Immune | Genes upregulated during transplant rejection/ alloimmune response to non-self-antigens expressed by donor tissues | 1.5268086 | 0.02 |
MTORC1_SIGNALING (Mammalian target of rapamycin complex 1) | Signaling | Genes upregulated through activation of mTORC1 complex | 1.5246518 | 0.02 |
Depleted host Pathways in PEDIS 4 | ||||
NAME | Process category | Description | NES | FWER p-val |
EPITHELIAL_MESENCHYMAL_TRANSITION | development | Genes defining epithelial–mesenchymal transition, as in wound healing, fibrosis, and metastasis | −1.9640744 | 0 |
MYOGENESIS | development | Genes involved in development of skeletal muscle (myogenesis) | −1.6926087 | 0 |
