Fig. 7: Involvement of C-type lectin receptors in the recognition of P. aeruginosa. | npj Biofilms and Microbiomes

Fig. 7: Involvement of C-type lectin receptors in the recognition of P. aeruginosa.

From: Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function

Fig. 7

P. aeruginosa biofilms, planktonic cells and high and low molecular weight biofilm carbohydrates were tested for their interaction with three important C-type lectins: DC-SIGN, MR and Dectin-2. DC-SIGN seems to play a dominant role in P. aeruginosa recognition based on its ability to bind biofilms, planktonic cells and purified biofilm carbohydrates, while Dectin-2 and MR preferentially bind purified biofilm carbohydrates. Functionally, purified biofilm carbohydrates interfere with DC-SIGN, Dectin-2 and, partially, MR activities and influence the phenotype of immune cells (moDCs). These findings implicate C-type lectins, particularly DC-SIGN, and to some extent Dectin-2, in the detection of P. aeruginosa infection and support a potential role for biofilm carbohydrates in modulating immunity to P. aeruginosa. DC-SIGN engagement and Dectin-2 blocking in a variety of innate immune cells such as DCs, macrophages and neutrophils could lead to immune evasion by reducing cellular activation.

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