Table 1 Domain composition of anti-Gardnerella endolysin candidates.

From: Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis

Endolysin Family

Endolysin domain type

 
 

EAD

CWB 1

CWB 2

Schematic

CCB2a

Glyco_hydro_25

Cw_7

Cw_7

CCB3

Amidase_2

RBP-likeb

 

CCB4

Glyco_hydro_25

RBP-likeb

 

CCB6

Glyco_hydro_25

Cw_binding_1

 

CCB7

Glyco_hydro_25

SH3b

 

CCB8

Glyco_hydro_25

SH3b

 

CCB9

Glyco_hydro_25

RBP-likeb

 

  1. aTruncated variants comprising a single Cw_7 were commonly observed within CCB2-family endolysins.
  2. bPutative in silico characterization of CWB domains as phage receptor binding protein (RBP) or phage baseplate protein homologues. Domain designation for endolysins schematics are as follows: green: glyco_hydro_25, blue: amidase_2, red: Cw_7, yellow: Cw_binding_1, orange: SH3b, and white: RBP-like. Black lines indicate endolysin domain linkers.
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