Fig. 5: Gut microbiota influenced host fecal and serum metabolomes in the worker group after 12 weeks of probiotic consumption. | npj Biofilms and Microbiomes

Fig. 5: Gut microbiota influenced host fecal and serum metabolomes in the worker group after 12 weeks of probiotic consumption.

From: Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

Fig. 5

a The interomic correlation networks of all variables for the gut microbiota and fecal and serum metabolomes of the workers at baseline and after the probiotic yogurt intervention. b Correlation of members of the differential MGS with fecal or serum metabolites associated with OS or antioxidation. Species that varied significantly between the two groups were identified using Metastats. Enrichment in either group is indicated using colored bars at the left and top of the plot. Significant correlations are denoted using stars (*p < 0.05, **p < 0.01, Student’s t test), and Benjamini–Hochberg adjustment was performed for multiple comparisons. In the heatmap, the legend denotes correspondingly the R value of Spearman. Exact p values are provided in the source data file. c Correlation of the levels of baseline-enriched (relevant to OS) and intervention-enriched metabolites (relevant to antioxidation) with microbial functions. The heatmap shows the Spearman’s correlation coefficients between fecal (red text) or serum (green text) metabolites and functional modules of GM. Significant correlations are denoted as +p < 0.05, *p < 0.01, and **p < 0.001. Source data and exact p values are provided in the source data file.

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