Fig. 1: Predicted 3D structure of P15s, antimicrobial susceptibility and activity of Lynronne 1, 2 and P15s.

a Predicted structure for peptide 15s: main-chain and side chains depicted in ribbon and stick representation, respectively, and coloured according to atom type: carbon, oxygen and nitrogen in green, red and blue, respectively. Figure rendered using PyMol. b Time-dependent kill of P. aeruginosa strains PAO1 and (c) LES431 by AMPs Lynronne 1, 2 and P15s at 3× MIC concentration. d AMP anti-biofilm establishment activity and efficacy against 24 h established biofilms of Pseudomonas strain PAO1 and (e) LES431 with Lynronne 1, Lynronne 2, and P15s shown as percentage biofilm reduction (OD570 nm) from untreated (growth control), significance calculated using single-factor ANOVA. For panels b–e, values are from three independent replicates and error bars represent standard deviation (when not visible, this is due to lack of variability).