Table 1 Susceptibility of P. aeruginosa isolates from cystic fibrosis infections to rumen microbiome-derived AMPs and comparator antibiotics measured by minimal inhibitory concentration and minimal bactericidal concentration.

				Lynronne 1		Lynronne 2		Lynronne 3		P15s		Levofloxacin		Polymyxin B
Source ID	Geographical location	Genome sequence	Details	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC	MIC	MBC	MIC
PA01	Genome sequenced isolate	Yes	High growth density at 15 h, high virulence	32	32	64	64	32	64	64	128	0.125	0.5	1
LES400	CF, Liverpool, U.K.	Yes	Transmissible, low growth density at 15 h, low virulence	16	32	16	32	32	32	32	32	1	2	—
LES431	CF, Liverpool, U.K.	Yes	Transmissible, low growth density at 15 h, low virulence	8	16	16	32	64	128	128	128	0.5	4	1–4
LESB58	CF, Liverpool, U.K.	Yes	Transmissible, low growth density at 15 h, low virulence	16	32	128	128	32	64	128	256	0.125	0.5	—
C3719	CF, Manchester, U.K.	Yes	Transmissible, paediatric, low growth density at 15 h, high virulence	64	128	32	32	32	64	64	128	0.125	0.5	—
AMT0060-2	Paediatric CF, Seattle, WA	No	Late isolate, high growth density at 15 h, high virulence, MIC of Ofloxacin, Carbenicillin and Tobramycin affected	64	64	32	32	128	128	128	128	0.125	2	—
AES-1R	Paediatric CF, Melbourne, Australia	Yes	Transmissible, low growth density at 15 h, high virulence.	64	64	64	128	256	256	512	>512	0.125	2	—
NH57388A	CF. Denmark	Yes	Low growth density at 15 h, low growth density at 15 h, alginate hyper-producer	32	64	32	64	128	256	256	512	0.5	4	—

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