Fig. 2: Intracellular and extracellular metabolomics in aging biofilms.
From: Impaired amino acid uptake leads to global metabolic imbalance of Candida albicans biofilms
Differentially abundant metabolites from each metabolite family were counted and plotted as a heat map. The extent of the metabolic changes is color-coded with darker fillings for bigger changes. The scale bar indicates the metabolite counts within one metabolite family. No significant changes are marked in gray. Cutoff p < 0.05 and log2FC ± 1. Source data are provided as a Source Data file. a The intracellular metabolite content increased after 24 h, but after 48 h of biofilm formation, many metabolites decreased significantly. The largest decline was observed for the nitrogenous substrates (amino acids and nucleotides). b Many metabolites accumulated in the extracellular metabolome in mature biofilms as amino acids and nucleotides were most abundant at the late time point.
