Fig. 8: Comparative intracellular and extracellular metabolomics of stp2Δ mutant vs. wild-type biofilms.
From: Impaired amino acid uptake leads to global metabolic imbalance of Candida albicans biofilms
Metabolomes from cells and media were analyzed for significant metabolic changes in stp2Δ mutant and wild-type biofilms. Analyzed contrasts were time point-adjusted. Numbers of metabolites with significant changes (Cutoff p < 0.05 and log2FC ± 1) were plotted for main metabolic families (a) and amino acids subgroups (b). Metabolite data were time point-adjusted (time point as a confounding variable) before comparative analysis. c Box plot diagram shows relative abundance (log2FC, median, upper and lower quartiles) of extracellular amino acids from wild-type (black) and stp2Δ (red) media, which were normalized to the respective amino acid concentrations from RPMI blank medium. Statistical differences between strains were calculated using the Student’s t-test and plotted next to the corresponding amino acid (* for p < 0.05). Source data are provided as a Source Data file.
