Fig. 6: Effects of the GM and SCFAs on GLU levels mediated by GPR109A. | npj Biofilms and Microbiomes

Fig. 6: Effects of the GM and SCFAs on GLU levels mediated by GPR109A.

From: Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis

Fig. 6

a Bray–Curtis distance-based PCoA analysis of the GM in the CON (blue), TD (red) and TFRD (green) groups of broiler chickens. b The top ten phyla of the GM in terms of abundance. c Differential abundances of firmicutes/bacteroidetes (F/B) ratios by phylum. d The top 20 most abundant GM constituents at the genus level. e Genus-level analysis of the GM using the random forest model. The abscissa indicates the importance of species to the classifier model, while the ordinates indicate the taxon names at the genus level. From top to bottom, the importance of species to the model decreases. f Venn diagrams of two sets of the top 20 species in terms of abundance and importance. g, h Differences in the abundances of GM components (Blautia and Coprococcus, respectively) at the genus level. i Ternary diagram showing the enrichment of seven SCFAs in the CON, TD and TFRD groups. Each side of the triangle represents a group. The closer the vertical distance from the bubble to the edge, the larger the proportion in the group. The size of the bubble indicates the SCFA abundance. j BA levels in caecal contents. k, l GPR109A levels in the pancreas and plasma (n = 6 broilers per group). m Spearman’s analysis of the correlations between gut-related metrics and GLU-related parameters. Red, positive correlation. Blue, negative correlation. *p < 0.05, **p < 0.01, and ***p < 0.001. Kruskal‒Wallis one-way ANOVA. The data are presented as the means ± SD.

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