Fig. 3: Bile acids composition in ND, HFD, and OCA groups and correlations between the abundance of bile acids and gut microbes in mice.
From: Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism
a, b Levels of serum bile acids in the mice between groups, a ND vs. HFD, b HFD vs. OCA. c, d Levels of fecal bile acid in the mice between groups, c ND vs. HFD, d HFD vs. OCA. e, f Correlations between gut microbes and serum bile acids in the mice between groups, e ND vs. HFD, f HFD vs. OCA. g, h Correlations between gut microbes and fecal bile acids in mice between groups, g ND vs. HFD, h HFD vs. OCA. HFD, the group of high-fat-diet-fed mice; ND, the group of normal-diet-fed mice; OCA, the group of mice treated with high-fat diet feeding and following OCA intervention. Red grids represented the positive correlation; blue grids represented the negative correlation; BA: bile acid. Wilcoxon rank-sum test and Spearman’s rank correlation, *P < 0.05; **P < 0.01; ***P < 0.001. In the box plots, horizontal line within the rectangle represents the median of all values, The top end of the box represents the upper quartile (75%), while the bottom end of the box represents the lower quartile (25%). The data are presented as means ± SD in the bar plots.
