Fig. 3: A. muciniphila inhibited the inflammatory effect on gingival epithelial cells caused by F. nucleatum by inhibiting the expression of TLR/MyD88/NF-κB pathways and secretion of inflammatory factors.
From: Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum
a Cluster analysis of inflammatory factor genes of human GECs treated by bacteria for 24 h (ordinate: gene number and name, abscissa: sample name, color indicates the expression of genes in this sample, red represents higher expression, blue represents lower expression). b–i Expression of TLR-2 (b), TLR-4 (c), MyD88 (d), NF-κB1 (e), IL-1β (f), IL-6 (g), IL-8 (h), and TNF-α (i) of human GECs infected for 24 h; j–l Secretion of IL-1β (j), IL-6 (k), and IL-8 (l) by human GECs infected for 24 h. Data are shown as the mean ± SD. Statistical significance was determined by One-way analysis of variance (ANOVA) and Student–Newman–Keuls test. *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant.
