Fig. 3: Fecal longitudinal beta diversity analyses. | npj Biofilms and Microbiomes

Fig. 3: Fecal longitudinal beta diversity analyses.

From: Oral and middle ear delivery of otitis media standard of care antibiotics, but not biofilm-targeted antibodies, alter chinchilla nasopharyngeal and fecal microbiomes

Fig. 3

Longitudinal analysis of changes in fecal weighted UniFrac beta diversity pairwise-distances across posttreatment intervals a baseline—2DPT, b baseline—5DPT, c baseline—7DPT, and d baseline—9DPT. Omnibus tests for differences between any of the nine cohorts for each interval were performed with Kruskal–Wallis tests in QIIME 2.0 (P < 0.05) and P values for each interval are displayed on respective graphs. Floating bar charts denote minimum, maximum, and median values for pairwise-distances within cohorts between the respective time point intervals. Chinchillas without values for both time points in the assessed interval were not included in analysis. e Principal coordinate analysis plot of fecal nonparametric microbial interdependence test (NMIT) distances at the genus level for samples from all treatments. Individual cones (AC cohorts) or spheres (all other cohorts) represent the longitudinal change in microbial composition of each chinchilla (n = 27) across the experimental period. Differences in NMIT distances between treatments were analyzed in QIIME 2.0 by PERMANOVA with 999 randomizations of the data (P < 0.05) with P values displayed on respective graphs. Cohorts are colored according to treatment as denoted in the legend.

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