Fig. 6: Histopathology, enzymology, and inflammatory level of the pancreas in mice after receiving AP-enriched and AP-depleted species. | npj Biofilms and Microbiomes

Fig. 6: Histopathology, enzymology, and inflammatory level of the pancreas in mice after receiving AP-enriched and AP-depleted species.

From: Integrative metagenomic and metabolomic analyses reveal the potential of gut microbiota to exacerbate acute pancreatitis

Fig. 6

a Histological evaluation of the pancreas revealed that the pathobionts-gavaged mice had more pancreatic edema, inflammatory infiltration, and acinar cell necrosis as compared with the sham-gavaged and AP-depleted species mice groups. b The pancreatic histological score among the three groups. c The serum level of amylase (left) and lipase (right) in mice after receiving the AP-enriched and AP-depleted species. d Immune cells infiltrating the pancreas were characterized by immunofluorescence detection of CD45, Ly6G, and F4/80. e–g The mean fluorescence intensity (MFI) of CD45, Ly6G, and F4/80 among the three groups. h, i The myeloperoxidase (MPO) activity and the levels of proinflammatory factors TNF-α and IL-1β of the pancreas in each group. For (b, c) and (e–i), data are shown as mean ± SD. One-way ANOVA analysis: *p < 0.05; **p < 0.01.

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