Fig. 1: Analysis of rarefied metagenomic profiles.

a Clustered taxonomic profiles of the 25 most abundant species present on nonlesional skin, patch, and plaque. Reads were rarefied to common depth prior to assignment of taxonomy. n = 32 metagenomic samples were left after rarefaction and included in the clustered heatmap. Displayed is the relative abundance in percent. b α-diversity (Shannon-Index) of n = 32 rarefied metagenomic samples (15 nonlesional, 8 patch, 9 plaque), one-way ANOVA corrected for multiple comparisons (Dunnett’s test), dot plots with median and interquartile range. c β-diversity (Bray-Curtis) dissimilarities, pairwise PERMANOVA, dot plots with median and interquartile range. 2 degrees of freedom in b and c.