Fig. 2: Differential abundance analysis of microbial species for N = 65 metagenomic samples.

a log2 fold-change (log2fc) of microbial species present on patch (n = 19) and plaque (n = 15) compared to nonlesonial skin (n = 31). b S. aureus relative abundance increases from nonlesional skin to plaque in the ΔSA-positive subgroup, while this is not the case for the other subgroup (ΔSA-neutral). c–g, Shannon-Index and relative abundances of bacteria stratified to ΔSA-subgroups. Shannon Index is based on n = 32 metagenomic samples rarefied to common depth as in Fig. 1b. Depicted are dot plots with median and interquartile range, Kruskal-Wallis test (b, d–g) or one-way ANOVA with correction for multiple comparisons.