Fig. 7: The TCR repertoire is affected by S. aureus. | npj Biofilms and Microbiomes

Fig. 7: The TCR repertoire is affected by S. aureus.

From: The skin microbiome stratifies patients with cutaneous T cell lymphoma and determines event-free survival

Fig. 7

a, b, α-diversity of the TCR repertoire in MF lesions and nonlesional skin. Plaque samples are stratified according to ΔSA-subgroup. c For each given pair of TCR and S. aureus epitope, a Binding Score (1 = perfect binding, 0 = no binding) was calculated. Epitopes were downloaded from the IEDB or, if not available, predicted for identified virulence factors of plaque-associated S. aureus strains. n = 275, displayed are the median (red), 1st and 3rd quantile, Kruskal-Wallis test corrected for multiple comparisons. d–k, Presentation of the top abundant TCRs in MF lesions and their contribution to the TCR repertoire in nonlesional skin and blood in the same patients. Counts represent the summed abundance of TCR clones and were normalized across all patients (by subsampling to common sequencing depth). Dominant clones in MF lesions were detectable in other tissues as well.

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