Fig. 5: Persistent and transient colonizing species drives the changes of host physiology.
From: Transient colonizing microbes promote gut dysbiosis and functional impairment
We identified the associations of PCS/TCS abundance changes with (A) clinical chemistry and hematology variables for disease diagnosis, (B) serum metabolomics, and (C) serum proteomics. A–C PCS/TCS abundances were significantly associated with clinical and hematological variables, metabolomics, and proteomics by linear mixed-effects models (p-value < 0.05). Significant positive (+) and negative associations (−) are marked on a heatmap (size proportional to significance). Interestingly, TCS microbes were associated with increasing toxic compounds, including indole-acetic acid (IAA), and deregulated immune functions. Metabolites with bold names were key metabolites associated with PCS/TCS, which were shown with their chemical structure and pathways in C and D. Metabolites with bold names were key metabolites associated with PCS/TCS, which were shown with their chemical structure and pathways in C and D. D We identified MGSs equipped with IAA and HA biosynthetic pathways (i.e., containing KEGG ortholog terms, K00466 and K01426 or K01451). We found their significant overlaps with TCS (Chi-square tests p-value < 0.01).
