Fig. 4: Akkermansia muciniphila induced compositional changes in the small-intestinal microbiota. | npj Biofilms and Microbiomes

Fig. 4: Akkermansia muciniphila induced compositional changes in the small-intestinal microbiota.

From: Akkermansia muciniphila in the small intestine improves liver fibrosis in a murine liver cirrhosis model

Fig. 4

A Bacterial load evaluated with qPCR of tuf gene in male animals in the liver cirrhosis (LC)-no treatment (NTx)2 group (n = 10) and the LC-Akkermansia (AKK) group (n = 10). B Shannon diversity index in male animals of the LC-NTx2 and LC-AKK groups. C Principal coordinates analysis (PCoA) plots based on weighted UniFrac distances of bacterial composition in the jejunum and ileum in male animals in the LC-NTx2 and LC-AKK groups. D Multivariate association analysis between two groups (the LC-NTx2 and LC-AKK groups) and bacterial composition at the genus level in the jejunum and ileum using samples from both sexes, with adjustment for sex (n = 20 in both the LC-NTx2 and LC-AKK groups). Data on bacterial load, Shannon index, and PCoA plots in female animals are shown in Supplementary Fig. 7. Data are means ± standard errors of the means. *p < 0.05, Mann–Whitney U test. Bacterial composition was compared with permutational analysis of variance.

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