Table 1 Genes potentially important to biofilm formation and epithelial adhesion and potential virulence gene (GBS)
From: Mechanisms of S. agalactiae promoting G. vaginalis biofilm formation leading to recurrence of BV
Accession | Gene | Transcript detected | Protein detected | Description |
|---|---|---|---|---|
EPS PRODUCTION AND BIOFILM FORMATION | ||||
WP_000052788 | sunS | NS | NS | glycosyltransferase family 2 protein |
WP_000848921 | SAG0417 | NS | NS | glycosyltransferase family 2 protein |
WP_001219472 | mgtA | Down | None | 1,2-diacylglycerol 3-glucosyltransferase |
WP_001050370 | rfaJ | NS | NS | glycosyltransferase family 8 protein |
WP_000428971 | pimB | NS | NS | glycosyltransferase family 4 protein |
WP_000241102 | SAG0014_06895 | NS | Up | glycosyltransferase family 2 protein |
WP_000976130 | arnC | NS | NS | glycosyltransferase family 2 protein |
WP_000867340 | spsA | None | NS | glycosyltransferase family 2 protein |
WP_001872148 | NCTC8181_01869 | NS | NS | SP_1767 family glycosyltransferase |
WP_000751415 | gspA_3 | NS | NS | CDP-glycerol |
WP_001196763 | yfdH | NS | NS | glycosyltransferase family 2 protein |
WP_001173122 | NS | NS | glycosyltransferase family 2 protein | |
WP_000159884 | luxS | NS | Up | S-ribosylhomocysteine lyase |
WP_000717641 | neuC | NS | None | UDP-N-acetylglucosamine 2-epimerase |
WP_000197731 | glgP | None | NS | glycogen/starch/alpha-glucan family phosphorylase |
WP_000410033 | Rgg2 | NS | NS | quorum-sensing system transcriptional regulator Rgg2 |
WP_000471420 | Rgg | None | NS | Rgg/GadR/MutR family transcriptional regulator |
EPITHELIAL ADHESION | ||||
WP_001040730 | tuf | None | None | elongation factor Tu |
WP_000090323 | fusA | None | Up | elongation factor G |
WP_000568636 | efp | None | None | elongation factor P |
WP_000260659 | gap | None | NS | type I glyceraldehyde-3-phosphate dehydrogenase |
WP_000703849 | pbsP | Down | NS | plasminogen-binding protein PbsP |
WP_000006733 | fbpA | None | None | fibronectin-binding domain-containing protein |
WP_000357571 | scpB | NS | NS | S8 family serine peptidase |
WP_001063293 | NCTC8181_01314 | Down | NS | LPXTG anchor domain surface protein |
WP_001872138 | srr | Down | NS | accessory Sec-dependent serine-rich glycoprotein adhesin |
WP_000489009 | NCTC8181_02011 | NS | NS | LPXTG anchor domain surface protein |
WP_079255211 | NS | NS | SpaH/EbpB family LPXTG-anchored major pilin | |
INVASION | ||||
WP_000910676 | yqfA | Down | NS | hemolysin III family protein |
WP_001101131 | cfb | None | Up | CAMP factor pore-forming toxin Cfb |
WP_001041036 | tlyA | None | NS | TlyA family RNA methyltransferase |
WP_000022832 | eno | None | Up | phosphopyruvate hydratase |
WP_000403405 | hylB | None | NS | hyaluronate lyase |
WP_000866344 | SAG0014_06175 | NS | NS | glycosyltransferase |
WP_000678279 | inlA_1 | NS | NS | pneumococcal-type histidine triad protein |
WP_000036813 | nox-2 | NS | NS | FAD-dependent oxidoreductase |
IMMUNE EVASION | ||||
WP_000578444 | cps2G | NS | NS | multidrug MFS transporter |
WP_000686634 | cpsF | NS | NS | UDP-N-acetylglucosamine--LPS N-acetylglucosamine transferase |
WP_000659576 | cpsE | NS | NS | sugar transferase |
WP_000197420 | cpsD | NS | None | tyrosine-protein kinase |
WP_001033070 | cap8A | NS | None | Capsular polysaccharide biosynthesis protein CpsC |
WP_000565377 | cpsB | NS | Up | tyrosine protein phosphatase |
WP_000974715 | sodA | NS | None | superoxide dismutase SodA |
WP_000357571 | scpB | NS | NS | S8 family serine peptidase |
WP_000277597 | rfbB | NS | Up | dTDP-glucose 4,6-dehydratase |
WP_000139158 | rfbC | NS | Up | dTDP-4-dehydrorhamnose 3,5-epimerase family protein |
WP_000676112 | rfbA | NS | Up | glucose-1-phosphate thymidylyltransferase RfbA |
WP_000783412 | sip | NS | None | LysM peptidoglycan-binding domain-containing protein |
WP_000953622 | rssA | NS | NS | patatin family protein |
MULTIDRUG RESISTANCE | ||||
WP_000919749 | dltD | NS | None | D-alanyl-lipoteichoic acid biosynthesis protein DltD |
WP_000613595 | dltB | NS | NS | D-alanyl-lipoteichoic acid biosynthesis protein DltB |
WP_000581010 | dltA | NS | Up | D-alanine--poly(phosphoribitol) ligase subunit DltA |
WP_000764820 | pbp2A | NS | Down | penicillin-binding protein PBP2A |
WP_000142548 | pbp2X | NS | NS | penicillin-binding protein PBP2X |
WP_000628377 | pbp1A | NS | Up | penicillin-binding protein PBP1A |
WP_000934659 | pbp2B | NS | NS | penicillin-binding protein PBP2B |
WP_000472390 | pbp1B | NS | Up | penicillin-binding protein PBP1B |
