Table 2 Genes potentially important to biofilm formation and epithelial adhesion and potential virulence gene (GV)
From: Mechanisms of S. agalactiae promoting G. vaginalis biofilm formation leading to recurrence of BV
Accession | Gene | Transcript detected | Protein detected | Description |
|---|---|---|---|---|
EPS PRODUCTION AND BIOFILM FORMATION | ||||
WP_004116793 | None | None | Glycosyltransferase Family 4 | |
WP_004111565 | Up | Up | Glycosyltransferase Family 2 | |
WP_009994689 | Down | None | Glycosyltransferase Family 2 | |
WP_009994540 | murG | None | None | Glycosyltransferase Family 28 |
WP_004115801 | None | Down | Glycosyltransferase Family 2 | |
WP_009994687 | None | None | Glycosyltransferase Family 2 | |
WP_013399469 | None | None | Glycosyltransferase Family 2 | |
WP_004112109 | None | NS | Crp/Fnr family transcriptional regulator | |
WP_004113527 | luxS | Up | NS | S-ribosylhomocysteine lyase |
WP_004115065 | NS | None | LysR substrate-binding domain-containing protein | |
WP_009993515 | NS | NS | serine acetyltransferase | |
WP_009993797 | glgP | None | NS | glycogen/starch/alpha-glucan phosphorylase |
EPITHELIAL ADHESION | ||||
WP_013399737 | Down | NS | SpaH/EbpB family LPXTG-anchored major pilin | |
WP_009993957 | Down | NS | LPXTG cell wall anchor domain-containing protein | |
WP_004113407 | None | NS | SpaH/EbpB family LPXTG-anchored major pilin | |
WP_048653142 | NS | NS | SpaH/EbpB family LPXTG-anchored major pilin | |
CYTOTOXICITY | ||||
WP_004573633 | vly | None | Down | cholesterol-dependent cytolysin vaginolysin |
WP_009994818 | rrmJ | NS | NS | TlyA family rRNA (cytidine-2’-O)-methyltransferase |
ANTIBIOTI/ANTIMICROBIAL RESISTANCE | ||||
WP_009994237 | None | NS | MATE family efflux transporter | |
WP_004138603 | bcrA | NS | NS | ABC transporter ATP-binding protein |
WP_004114222 | NS | NS | ABC transporter permease | |
WP_009993638 | NS | NS | FemA/FemB family protein | |
WP_004116956 | None | NS | Multidrug efflux MFS transporter | |
WP_009994347 | NS | NS | ABC transporter ATP-binding protein/permease | |
WP_029600583 | NS | NS | ABC transporter ATP-binding protein/permease | |
WP_004118354 | NS | NS | C1 family peptidase | |
WP_009993807 | None | NS | Phosphotransferase | |
WP_009994439 | None | NS | VTT domain-containing protein | |
IMMUNE EVASION | ||||
WP_004115062 | ahpC | None | NS | Alkyl hydroperoxide reductase subunit C |
WP_048653136 | NS | NS | Rib/alpha-like domain-containing protein | |
IRON ACQUISITION | ||||
WP_004573592 | None | NS | DNA starvation/stationary phase protection protein | |
WP_009994324 | None | NS | FTR1 family iron permease | |
WP_004114233 | NS | None | Iron transporter | |
WP_009994119 | hemW | None | None | Radical SAM family heme chaperone HemW |
WP_004113597 | NS | NS | Transcriptional repressor | |
WP_009993984 | NS | NS | Cysteine hydrolase | |
MUCIN DEGRADATION | ||||
WP_013399386 | Up | NS | Glycoside hydrolase | |
WP_009993891 | None | NS | Alpha-L-fucosidase | |
WP_009993889 | None | Up | DUF4981 domain-containing protein | |
WP_009993756 | Up | None | Alpha-mannosidase | |
WP_013399577 | TsaD | NS | NS | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD |
WP_004117227 | TsaB | NS | Up | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB |
OTHERS | ||||
WP_009994837 | None | NS | C40 family peptidase | |
WP_048653118 | NS | NS | GA module-containing protein | |
WP_004112601 | NS | None | MetQ/NlpA family ABC transporter substrate-binding protein | |
