Fig. 5: Statistically significant associations with microbiome diversity, composition, and unique functional KOs richness.

a Phenotypes associated with the species-level microbiome taxonomic composition. b Phenotypes associated with the microbiome function composition. c Variance in microbiome composition and function explained by phenotype groups in multivariate PERMANOVA analysis. The bar plot indicates the explained variance in the interindividual variation of the microbial composition obtained by the permutational analysis of variance (based on the Bray-Curtis distance). The heatmap shows the Spearman correlation coefficients of each phenotype with the Shannon diversity index and the observed species richness. The group of blood measurement and diet only showed the top 15 factors in the graphs. Blue indicates a negative correlation, and red indicates a positive correlation. *FDR <0.05, **FDR <0.01, ***FDR <0.001.