Fig. 1: NEVs have excellent biocompatibility. | npj Biofilms and Microbiomes

Fig. 1: NEVs have excellent biocompatibility.

From: Bifidobacterium longum NSP001-derived extracellular vesicles ameliorate ulcerative colitis by modulating T cell responses in gut microbiota-(in)dependent manners

Fig. 1

A Schematic diagram of in vitro simulated digestion. In this in vitro simulation of the digestive system, saliva fluid (alpha amylase), gastric fluid (pepsin), and intestinal fluid (pancreatic enzymes and bile acids) are used to profile oral-gastrointestinal digestive conditions. B Plot of particle size before and after digestion of NEVs. C, D Transmission electron microscopy of NEVs before and after digestion, scale bar: 100 nm. E, G The effects of different concentrations of NEVs on the viability of RAW264.7 or Caco-2 cells, n = 6 (The cell experiment diagrams were created with Figdraw). F, H Schematic diagram of NEVs internalization by RAW264.7 or Caco-2 cells. The cell nucleus was stained by DAPI (Blue), and NEVs were labeled by lipophilic carbocyanine dye, AF647 (Red), n = 3, scale bar: 25 μm. NEVs: B. longum NSP001 extracellular vesicles.

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