Fig. 3: NEVs alleviate DSS-induced colitis severity. | npj Biofilms and Microbiomes

Fig. 3: NEVs alleviate DSS-induced colitis severity.

From: Bifidobacterium longum NSP001-derived extracellular vesicles ameliorate ulcerative colitis by modulating T cell responses in gut microbiota-(in)dependent manners

Fig. 3

A Schematic diagram of the animal experimental program (n = 5). B Changes in body weight (n = 5). C Disease activity index (DAI) scores (n = 5). D Representative images of colon length (n = 5). E Quantification of colon length (n = 5). F Spleen index, spleen index % = spleen mass/mouse body weight × 100% (n = 5). G Representative images of HE staining (n = 5), scale bar: 500 μm and 100 μm. H HE staining score (n = 5). Data were shown as means ± SEM. Significance was assessed using the one-way or two-way ANOVA test, giving P values: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. NEVs B. longum NSP001 extracellular vesicles, DSS dextran sulfate sodium, FACS fluorescence-activated cell sorting, HE hematoxylin-eosin.

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