Fig. 4: NEVs ameliorate DSS-induced intestinal barrier damage in mice. | npj Biofilms and Microbiomes

Fig. 4: NEVs ameliorate DSS-induced intestinal barrier damage in mice.

From: Bifidobacterium longum NSP001-derived extracellular vesicles ameliorate ulcerative colitis by modulating T cell responses in gut microbiota-(in)dependent manners

Fig. 4

A Representative image of AB-PAS staining (n = 5), scale bar: 100 μm. B The number of goblet cells counted for the colon (n = 5). C Representative images of MUC2 immunohistochemistry (n = 5), scale bar: 100 μm. F, I Representative images of colonic ZO-1 and OCCLUDIN measured by immunofluorescence (n = 5), scale bar: 50 μm. D, G, J Quantification of MUC2, ZO-1, and OCCLUDIN (n = 5). E, H, K The mRNA expression levels of Muc2, Zo-1, and Occludin in the colon (n = 5). Data were shown as means ± SEM. Significance was assessed using the one-way ANOVA test, giving P values: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. NEVs B. longum NSP001 extracellular vesicles, DSS dextran sulfate sodium, AB-PAS alcian blue periodic acid-schiff.

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