Fig. 3: Ulcerative colitis disrupts the balance of gut microbes involved in succinate production and metabolism in both humans and mice.
From: Gut commensals-derived succinate impels colonic inflammation in ulcerative colitis
A Schematic of stool specimen collection for metagenomics and qPCR. B Heatmap showing the top ten microbiota families with their respective relative abundances (n = 4). Bacteroidaceae was abundant in the Oxa-colitis group compared to the other families. C Venn diagram showing the relative abundance (%) of top families between healthy controls and Oxa-colitis. D Heat tree analysis depicting alterations in microbiota composition between healthy controls and Oxa-colitis. Significantly altered taxa are displayed by name at the corresponding node. Nodes indicate the hierarchical structure of taxa. A blue branch indicates a decrease in healthy controls compared to Oxa-colitis. E Relative abundance of individual species of the Bacteroidaceae family in stool specimens collected from healthy controls and the Oxa-colitis group. F Relative abundance of individual species of the Acidaminococcaceae family in stool specimens collected from healthy controls and the Oxa-colitis group. G Compared to healthy individuals, UC patients have a significant increase in the abundance of Bacteroidaceae, the major producers of succinate in the gut microbiota, and a decrease in Acidaminococcaceae, which is important for succinate metabolism. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 (One-way ANOVA or two-way ANOVA).
