Fig. 5: Putative metabolic rectal signatures depleted in endometrial cancer.

Amino acid and polyphenol pathways in EC samples when compared to benign conditions in rectal samples. Enrichment in putative metabolic pathways generated by PiCrust2 among EC patients (orange) when compared to benign conditions (light blue) prior (A) and after adjusting for BMI and menopausal status (B). ANCOM-BC was utilized to determine differentially abundant putative pathways where p < 0.05 was deemed significant. Pathways with a LFC > 1 are colored based on disease group; pathways in gray are below LFC < 1. C Map of pathways relating to polyphenol metabolism and antimicrobial biosynthesis in EC compared to benign conditions. D Enrichment in putative metabolic pathways among EC patients, comparing EEC patients (light orange) to other ECs. The pathway enrichment was performed utilizing ANCOM-BC. The threshold was LFC > 1, and pairwise comparisons were made using Bonferroni multiple testing correction. E Map of pathways relating to polyphenol metabolism and antimicrobial biosynthesis in 1/2 EEC compared to Other ECs.