Table 1 Demographic/clinical information
From: Navigating complexities of polymorphic microbiomes in endometrial cancer
All | Benign Gynecologic Conditions | Endometrial Hyperplasia | Grade 1/2 EEC | Other Ecs | p value for the difference among diseases | ||||
|---|---|---|---|---|---|---|---|---|---|
(n=192) | (n=108) | (n=18) | (n=53) | (n=13) | |||||
overall | Paired | ||||||||
Age (mean (S.D.)) (n=192) | 51.02 (12.45) | 45.55 (10.01) | 54.11 (13.35) | 58.73 (11.82) | 60.77 (8.06) | <0.0001 | B vs H | 0.007 | |
B vs EEC | <0.0001 | ||||||||
B vs Other EC | <0.0001 | ||||||||
Race (n (%)) (n=190) | |||||||||
American Indian/Alaskan | 15 (7.89) | 5 (4.67) | 1 (5.56) | 8 (15.38) | 1 (7.69) | 0.004 | B vs EEC | 0.02 | |
Asian/Far East/South East | 4 (2.11) | 4 (3.74) | 0 (0.00) | 0)0.00) | 0 (0.00) | ||||
Asian/Indian | 1 (0.53) | 0 (0.00) | 1 (5.56) | 0 (0.00) | 0 (0.00) | ||||
Native Hawaiian/Pacific Islander | 1 (0.53) | 0 (0.00) | 0 (0.00) | 1 (1.92) | 0 (0.00) | ||||
White/Caucasian | 142 (74.74) | 78 (72.90) | 16 (88.89) | 37 (71.15) | 11 (84.62) | ||||
Black or African American | 12 (6.32) | 11 (10.28) | 0 (0.00) | 1 (1.92) | 0 (0.00) | ||||
Middle Eastern/North African | 1 (0.53) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (7.69) | ||||
Mixed or Multi-Racial | 9 (4.74) | 7 (6.54) | 0 (0.00) | 2 (3.95) | 0 (0.00) | ||||
Not specified, other | 5 (2.63) | 2 (1.87) | 0 (0.00) | 3 (5.77) | 0 (0.00) | ||||
Ethnicity (n=191) | |||||||||
Non-Hispanic | 141 (73.82) | 76 (70.37) | 14 (77.78) | 41 (78.85) | 10 (76.92) | 0.67 | |||
Hispanic | 50 (26.18) | 32 (29.63) | 4 (22.22) | 11 (21.15) | 3 (23.08) | ||||
Income (n=168) | |||||||||
<10,000 | 8 (4.60) | 3 (3.03) | 0 (0.00) | 5 (11.36) | 0 (0.00) | ||||
10,000-25,000 | 26 (14.94) | 10 (10.10) | 6 (42.86) | 7 (15.91) | 3 (27.27) | 0.002 | B vs H | 0.07 | |
25,000-50,000 | 39 (22.41) | 13 (13.13) | 3 (21.43) | 16 (36.36) | 4 (36.36) | B vs EEC | 0.0004 | ||
50,000-75,000 | 32 (18.39) | 23 (23.23) | 2 (14.29) | 6 (13.64) | 1 (9.09) | ||||
75,000-100,000 | 18 (10.34) | 15 (15.15) | 1 (7.14) | 1 (2.27) | 1 (9.09) | ||||
>100,000 | 32 (18.39) | 24 (24.24) | 1 (7.14) | 3 (6.82) | 2 (18.18) | ||||
Don’t know/refused | 19 (10.32) | 11 (11.11) | 1 (7.14) | 6 (13.64) | 0 (0.00) | ||||
Vaginal pH (n=192) | |||||||||
≤4.5 | 118 (61.46) | 83 (76.85) | 13 (72.22) | 17 (32.08) | 5 (38.46) | ||||
>4.5 | 74 (61.54 | 25 (23.15) | 5 (27.78) | 36 (67.92) | 8 (61.54) | <0.0001 | B vs EEC | <0.0001 | |
B vs Other EC | 0.006 | ||||||||
H vs EEC | 0.005 | ||||||||
BMI (n=192)) | |||||||||
<25 | 29 (15.38) | 23 (21.30) | 0 (0.00) | 4 (7.55) | 2 (15.38) | ||||
25–29 | 47 (24.38) | 38 (35.19) | 1 (5.56) | 6 (11.32) | 2 (15.38) | <0.0001 | B vs H | <0.0001 | |
30–34 | 30 (15.63) | 19 (17.59) | 2 (11.11) | 6 (11.32) | 3 (23.08) | B vs EEC | <0.0001 | ||
≥35 | 86 (44.79) | 28 (25.93) | 15 (83.33) | 37 (69.81) | 6 (46.15) | ||||
Menopausal status (n=190) | |||||||||
Pre | 108 (56.84) | 89 (82.41) | 6 (33.33) | 12 (23.53) | 1 (7.69) | ||||
Post | 82 (43.16) | 19 (17.59) | 12 (66.67) | 39 (76.47) | 12 (92.31) | <0.0001 | B vs H | <0.0001 | |
B vs EEC | <0.0001 | ||||||||
B vs Other EC | <0.0001 | ||||||||
Combined contraceptives | |||||||||
Hormonal (n=138) | |||||||||
Yes | 36 (26.09) | 26 (32.10) | 0 (0.00) | 5 (14.71) | 5 (45.45) | ||||
No | 102 (73.91) | 55 (67.90) | 12 (100.00) | 29 (85.29) | 6 (54.55) | 0.01 | B vs H | 0.02 | |
B vs EEC | 0.06 | ||||||||
H vs Other EC | 0.01 | ||||||||
Non-hormonal (n=64) | EEC vs Other EC | 0.048 | |||||||
Yes | 2 (3.13) | 1 (2.50) | 0 (0.00) | 1 (7.14) | 0 (0.00) | ||||
No | 62 (96.88) | 39 (97.50 | 6 (100.00) | 13 (92.86) | 4 (100.00) | 0.62 | |||
D&C (n=192) | |||||||||
Yes | 58 (30.21) | 19 (17.59) | 7 (38.89) | 25 (47.17) | 7 (53.85) | ||||
No | 134 (69.79) | 89 (82.41) | 11 (61.11) | 28 (52.83) | 6 (46.15) | 0.0002 | B vs H | 0.056 | |
B vs EEC | 0.0001 | ||||||||
B vs Other EC | 0.007 | ||||||||
Parity (n=191) | |||||||||
0 | 44 (23.04) | 22 (20.56) | 4 (22.22) | 15 (28.30) | 3 (23.08) | 0.3 | |||
1 | 24 (12.57) | 9 (8.41) | 4 (22.22) | 8 (15.09) | 3 (23.08) | ||||
2 | 42 (21.99) | 23 (21.50) | 7 (38.89) | 10 (18.87) | 2 (15.38) | ||||
3 | 44 (23.04) | 27 (25.23) | 2 (11.11) | 13 (24.53) | 2 (15.38) | ||||
4+ | 37 (19.37) | 26 (24.30) | 1 (5.56) | 7 (13.21) | 3 (23.08) | ||||
Heavy periods (n=150) | |||||||||
Light | 9 (6.00) | 5 (5.32) | 0 (0.00) | 2 (5.88) | 2 (20.00) | 0.01 | B vs EEC | 0.01 | |
Mod | 48 (32.00) | 21 (22.34) | 6 (50.00) | 17 (50.0) | 4 (40.00) | B vs Other EC | 0.05 | ||
Heavy | 93 (62.00) | 68 (72.34) | 6 (50.00) | 15 (44.12) | 4 (40.00) | ||||
Tobacco use (n=184) | |||||||||
Yes | 19 (10.33) | 14 (13.46) | 1 (5.56) | 3 (6.12) | 1 (7.69) | 0.15 | |||
No | 55 (29.89) | 34 (32.69) | 4 (22.22) | 13 (26.53) | 4 (30.77) | ||||
Never | 89 (48.37) | 47 (45.19) | 12 (66.67) | 22 (44.90) | 8 (61.54) | ||||
Quit | 21 (11.41) | 9 (8.65) | 1 (5.56) | 11 (22.45) | 0 (0.00) | ||||
Douching (n=161) | |||||||||
Yes | 26 (16.15) | 15 (15.96) | 3 (21.43) | 7 (16.28) | 1 (10.00) | 0.9 | |||
No | 135 (83.85) | 79 (84.04) | 11 (78.57) | 36 (83.72) | 9 (90.00) | ||||
Diabetes (n=192) | |||||||||
Yes | 48 (25.00) | 22 (20.37) | 5 (27.78) | 21 (39.62) | 0 (0.00) | 0.006 | B vs EEC | 0.01 | |
No | 144 (75.00) | 86 (79.63) | 13 (72.22) | 32 (60.38) | 13 (100.00) | H vs Other EC | 0.05 | ||
EEC vs Other EC | 0.01 | ||||||||
Hypertension (n=192) | |||||||||
Yes | 65 (33.85) | 25 (23.15) | 6 (33.33) | 27 (50.94) | 7 (53.85 | 0.002 | B vs EEC | 0.001 | |
No | 127 (66.15) | 83 (76.85) | 12 (66.67) | 26 (49.06) | 6 (46.15) | B vs Other EC | 0.04 | ||
