Fig. 7: Serum metabolomic profiles in LOS and HOS cows (n = 9). | npj Biofilms and Microbiomes

Fig. 7: Serum metabolomic profiles in LOS and HOS cows (n = 9).

From: Multi-omics profiling of dairy cattle oxidative stress identifies hindgut-derived Phascolarctobacterium succinatutens exhibiting antioxidant activity

Fig. 7

a OPLS-DA scores plot of the serum metabolome. b Volcanic plot of differential serum metabolites in the LOS and HOS (control) groups. Metabolites in the LOS group compared with those in the HOS group showed varying degrees of up- or downregulation (red and blue, respectively) (P < 0.05). c VIP score scatter plot of the top 20 differential metabolites between LOS and HOS groups (P < 0.05). Colors denote upregulation (red) or downregulation (green) in corresponding group. d The KEGG enrichment analysis bubble chart. Each bubble represents a metabolic pathway. The bubble size indicates pathway significance, and its color reflects the pathway impact value from topology analysis. Lighter colors denote lower impact, and darker colors denote higher impact. e Spearman’s correlations between altered signature microbial species and their impact on differential serum metabolites. The circles superimposed on diamonds represent the significance of individual microbial species. The bar chart summarizes the total explained variations of microbial species, integrating this information with the heatmap. KYN, FHK, and HDA denote the kynurenine, formyl-5-hydroxykynurenamine, and 5-hydroxyindole-3-acetic acid, respectively. Signature bacteria names are labeled red.

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