Fig. 2: Identification of prognostic bacterial biomarkers associated with PFS in colorectal cancer patients.
From: Oral microbiota signature predicts the prognosis of colorectal carcinoma
A Kaplan–Meier curve illustrating PFS stratified by the detection status of identified oral bacterial species. P values were calculated using the log-rank test. Numbers below each graph indicate the number of patients at risk at different time points. ND not detected, Det detected, PFS progression-free survival. B Volcano plot showing the hazard ratio (HR) and statistical significance of candidate prognostic bacterial species. The x axis represents log2-transformed HR, while the y axis shows −log10-transformed false discovery rates (FDR). Circle size indicates the frequency of significance in 1000 cross-validation tests using univariate Cox regression, and color intensity (gray to red) represents the frequency of significance in multivariate Cox regression analysis. The multivariate Cox regression model was adjusted for age, sex, tumor stage, and neoadjuvant chemoradiotherapy.
