Fig. 4: Fusobacterium nucleatum abundance by individual and tumor characteristics.
From: Fusobacterium nucleatum is enriched in invasive biofilms in colorectal cancer
Relative abundance by 16S rRNA amplicon sequencing of Fusobacterium nucleatum in pairs of tumor (blue circle) and normal (clear circle), stratified by A sex, B age, C ethnicity, D tumor location, E tumor stage, F biofilm (BF) status, and G both biofilm status and tumor stage. Bars indicated median. Of 112 individuals with CRC in the study, 108 tumor and normal pairs were available for 16S rRNA sequencing analysis. Numbers below each graph depict the number of samples out of the total in which F. nucleatum was not detected by sequencing. Analyzed by two-tailed Wilcoxon matched-pairs signed rank test, with p < 0.05 considered significant. EO-CRC early-onset colorectal cancer. LO-CRC late-onset colorectal cancer. See Fig. S7 for abundance of F. nucleatum as a sum of confident and ambiguous species assignments, stratified by biofilm status. H Matrix of F. nucleatum and other oral biofilm organism abundances in tumor samples, analyzed by nonparametric Spearman correlation coefficient. See Fig. S8 for relative abundance of each organism in the matrix in tumor/normal pairs.
