Fig. 4: Association of the COVID-19 and its severity with the functions of the microbiota of Moroccan and French patients.
From: Gut microbiota alterations are linked to COVID-19 severity in North African and European populations
PCoA were built from Bray-Curtis (a, b) dissimilarity matrices constructed from the normalized abundance of pathways in microbiota (severity analyzes are based on Moroccan population only). Ellipses were drawn around the centroids of each emerging community at 95% (inner) and 97% (outer) confidence intervals. c Result of the MaAsLin2 analysis for the L-tryptophan biosynthesis pathway. d Tryptophan metabolites whose abundance was significantly different between healthy subjects, severe COVID-19 patients, and non-severe ones. Kruskal-Wallis tests with Dunn’s test post-hoc (Benjamini-Hochberg p-value correction method) were used to compare the three groups. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. e Spearman’s correlation between microbiota species and the abundance of L-Tryptophan metabolites in Moroccan patients. Only correlations with a q-value < 0.1 were represented in the heatmap. Colors represent the strength of the correlation. The numbers correspond to clusters based on correlation similarity.
