Fig. 4: FMT and AKK replantation rescues the phenotype of exacerbated colitis caused by TSP50 deficiency in NSCs.
From: TSP50 deficiency in neural stem cells aggravates colitis in mice by altering intestinal microbiome
a Scheme of FMT and AKK replantation protocol. b Body weight loss after DSS treatment (n = 6). c, d The DAI scores and survival rates after DSS treatment (n = 6). e Colon lengths and quantification after DSS treatment (n = 6). f Representative HE staining and histopathological scores of colon tissues after DSS treatment (n = 6). Scale bar: 50 μm. g ELISA analysis of serum TNF-α levels after DSS treatment (n = 4). h ELISA analysis of serum IL-6 levels after DSS treatment (TSP50fl/fl, n = 3; TSP50fl/flNestinCre, n = 3; FMT-TSP50fl/flNestinCre, n = 4; AKK-TSP50fl/flNestinCre, n = 4). Values were expressed as means ± SEM. Two‑way ANOVA was used to analyze (b, c), one‑way ANOVA was used to analyze (e, f, g, h). ns (no significance), * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
