Fig. 1: Residues of DEHP and its effects on fertility and ovarian function in mice. | npj Biofilms and Microbiomes

Fig. 1: Residues of DEHP and its effects on fertility and ovarian function in mice.

From: Di (2-ethylhexyl) Phthalate decrease pregnancy rate via disrupting the microbe-gut-hypothalamic-pituitary-ovarian axis in mice

Fig. 1

A The DEHP residues in the blood (μg/L), hypothalamus and intestine (μg/kg) of mice. B Alterations in body weight observed in mice exposed to DEHP. C Pregnancy rate in mice subjected to short-term and long-term DEHP treatments. D Litter size in mice subjected to short-term and long-term DEHP treatments. For the short-term DEHP treatment group, the Mann–Whitney U test was used, while for the long-term DEHP treatment group, the Student’s t test was applied (**p < 0.01). E Histological examination (H.E. staining) of ovarian tissue and a chart of the follicle count (n = 3, Student’s t test, **p < 0.01; ***p < 0.001). The image on the right represents a magnified view of the region enclosed by the black box in the image on the left. The black arrows indicate the location of atretic follicles. Scale bar for the left image: 100 µm. Scale bar for the right image: 20 µm.

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