Fig. 1: Oxidative stress induces ferroptosis in sow mammary glands and inhibits milk fat synthesis. | npj Biofilms and Microbiomes

Fig. 1: Oxidative stress induces ferroptosis in sow mammary glands and inhibits milk fat synthesis.

From: Lactobacillus amylovorus extracellular vesicles mitigate mammary gland ferroptosis via the gut-mammary gland axis

Fig. 1

a Distribution of oxidative stress levels in sows (n = 63). b Experimental grouping and sampling plan for sows, created with BioRender. c Total oxidative status in blood (n = 10). d Total antioxidant status in blood (n = 10). e Oxidative stress index in blood (n = 10). f Glutathione (GSH) levels in blood (n = 10). g Malondialdehyde (MDA) levels in blood (n = 10). Correlation between fat (h), protein (i), and lactose (j) contents and oxidative stress index (OSI) in colostrum (n = 63). Contents of fat (k), protein (l), and lactose (m) in colostrum (n = 10). Levels of GSH (n), MDA (o) in milk-derived somatic cells (n = 10). p Western blot analysis and fold change of milk fat synthesis-related proteins in colostrum-derived cells (n = 3). q mRNA expression of milk fat synthesis-related genes in colostrum-derived cells (n = 3). r Western blot analysis and fold change of milk fat transport-related proteins in colostrum-derived cells (n = 3). s mRNA expression of milk fat transport-related genes in colostrum-derived cells (n = 3). t Western blot analysis and fold change of ferroptosis-related proteins in colostrum-derived cells (n = 3). u mRNA expression of ferroptosis-related genes in colostrum-derived cells (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001; ns not significant (P > 0.05). HOS sows under high oxidative stress, LOS sows under low oxidative stress.

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