Fig. 1: F.nucleatum promoted periodontal and intestinal destruction in mice. | npj Biofilms and Microbiomes

Fig. 1: F.nucleatum promoted periodontal and intestinal destruction in mice.

From: Periodontitis-associated Fusobacterium nucleatum promotes ulcerative colitis by ferroptosis-mediated gut barrier disruption

Fig. 1

A Schematic representation and study design. B The survival rate of mice (% of initial) (n = 10). C Weight change of mice (% of initial) (n = 10). D Disease activity index (DAI) scores of mice (n = 10). E Representative images of the colon and F quantification of colon length (scale: 1 cm) (n = 5). G Histological images of the colon (scale: 50 μm) (left) and the H&E score (right). Yellow “*” indicates inflammatory cell infiltration, and yellow arrows indicate epithelial disruption (n = 8). H Histological images of the periodontium (scale: 200 μm). AL alveolar bone, PDL periodontal ligament, D dentin, black arrows: stripped junction epithelium (n = 5). I Representative Micro CT images (scale: 10 μm), Yellow line: ABC, red line: CEJ (n = 5). J The analysis of the distance from the cement-to-enamel junction-alveolar bone crest, CEJ-ABC (mm), the value of bone volume/tissue volume, BV/TV (%), bone surface area-tissue volume ratio, (BS/TV) (1/mm) and the trabecular separation, Td.Sp (mm). All data represent the mean ± SEM. Each dot indicated an individual mouse. *P < 0.05, **p < 0.01, ***P < 0.001, ****p < 0.0001, by one-way or two-way ANOVA, followed by a post hoc test.

Back to article page