Fig. 6: Associations between cervicovaginal immune mediators, vaginal microbiota and ABO blood group at timepoint 2 (20 + 0-23 + 6). | npj Biofilms and Microbiomes

Fig. 6: Associations between cervicovaginal immune mediators, vaginal microbiota and ABO blood group at timepoint 2 (20 + 0-23 + 6).

From: ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth

Fig. 6

a CVF IL-8 – classified as normal or high (according to tertile) by ABO blood group and Lactobacillus Crispatus dominance (defined as 80% relative abundance) with the shading in each quadrant indicating the percentage of sPTB <34 weeks gestational age at is shown in. b Correlation plots for gestational age at delivery, Lactobacillus crispatus proportion, CVF IL-8 and IL-1β concentrations for blood groups A (yellow), B (red) and O (blue) are shown in. (c-e), Canonical Correlation Analysis between 20 dominant bacterial taxa across samples (shown in blue) and CVF immune analytes (shown in red). Objects that are close together are correlated with each other. Distance from the centre represents strength of association. c Blood group A (n = 82). d blood group B (n = 33). e Blood Group O (n = 98). List of 20 dominant taxa: Lactobacillus crispatus, Lactobacillus iners, Gardnerella vaginalis, Lactobacillus gasseri, Lactobacillus jensenii, Bifidobacterium, Atopobium vaginae, Streptococcus, Lactobacillus spp., Prevotella timonensis, Aerococcus, Lachnospiraceae, Prevotella bivia, Prevotella amnii, Anaerococcus, Rothia, Finegoldia, Peptoniphilus, Atopobium rimae, Fusobacterium.

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