Fig. 4: Untargeted metabolomics revealed significant changes in the gut metabolic profile of ICU patients following carbapenem-resistant Klebsiella pneumoniae (CRKP) intestinal colonization. | npj Biofilms and Microbiomes

Fig. 4: Untargeted metabolomics revealed significant changes in the gut metabolic profile of ICU patients following carbapenem-resistant Klebsiella pneumoniae (CRKP) intestinal colonization.

From: Microbiome-mediated colonization resistance to carbapenem-resistant Klebsiella pneumoniae in ICU patients

Fig. 4

A OPLS-DA analysis indicated significant differences in the untargeted metabolomic profiles between healthy individuals and ICU patients. B The top 25 enriched metabolites displayed in panel (B). C A random forest algorithm identified the top 20 most important differential metabolites. Similarly, significant differences were observed between CRKP-negative patients (CRKP-N) and CRKP-positive patients (CRKP-P) (D–F), CRKP-positive patients (CRKP-P) and their corresponding baseline samples upon admission (CRKP-PA) (G–I), as well as CRKP-negative patients (CRKP-N) and their admission samples (CRKP-NA) (J–L).

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