Table 1 Results of growth simulations of single (S) and co-culture (C) of candidate GABA-producers using metabolic reconstructions

Consortium	Composition	Medium	Growth rate (h⁻¹)	GABA (mmol gDW⁻¹h⁻¹)	Butyrate (mmol gDW⁻¹h⁻¹)
S1	LSYM	INU	0.06	0	0
S2	LSYM	GLC	0.30	0	0
S3	CEUT	INU	0.00	0	0
S4	CEUT	GLC	0.21	0	3.32
S5	PDOR	INU	0.20	0	0
S6	PDOR	GLC	0.56	0	0
S7	BTHE	INU	0.82	0.82	0
S8	BTHE	GLC	0.82	0.82	0
S9	LBRE	INU	0.16	0	0
S10	LBRE	GLC	0.78	0	0
S11	LPLA	INU	0.00	0	0
S12	LPLA	GLC	0.34	0	0
S13	BADO	INU	0.25	1.21	0
S14	BADO	GLC	0.55	0.35	0
S15	LPAR	INU	0.11	0	0
S16	LPAR	GLC	0.34	0	0
S17	PVUL	INU	0.28	0	0
S18	PVUL	GLC	0.79	0	0
C1a	BADO-BTHE	INU	0.33	0.66	0
C2a	BADO-BTHE-PVUL	INU	0.37	1.34	0
C1b	LPLA-CEUT	GLC	0.28	0.73	1.54
C2b	LBRE-CEUT	GLC	0.25	1.49	3.06
C3b	LPLA-CEUT-BADO	GLC	0.30	1.37	1.47
C4b	LBRE-CEUT-BADO	GLC	0.29	1.48	2.93
C5b	LPLA-LBRE-CEUT	GLC	0.30	1.37	0.74
C6b	LPLA-BTHE-BADO-CEUT	GLC	0.31	1.36	2.63
C7b	LPLA-BADO-CEUT	GLC	0.30	1.35	1.96
C8b	LPLA-LBR-CEUT-BADO	GLC	0.29	1.45	1.96
C9b	LBRE-BTH-CEUT-BADO	GLC	0.28	1.48	4.39
C10b	LBR-BDOR-CEUT-BADO	GLC	0.29	1.63	2.47
C11b	BADO-CEUT	INU	1.23	0.87	0.05
C12b	LPLA-CEUT-BADO-LBRE-BTH	GLC	0.30	1.35	1.98
C13b	LPLA-CEUT-BTH-BADO-LBRE	GLC	0.29	1.43	2.29
C14b	LPLA-CEUT	GLC	0.30	1.36	2.63
C1c	LBRE-LPAR	GLC	0.31	0.66	0
C2c	LPLA-LPAR	INU	0.43	1.22	0
C3c	BADO-LPAR	INU	0.55	1.21	0
C4c	BTHE-LPAR	GLC	0.31	0.66	0
C5c	BADO-BTHE-LPAR	INU	1.22	0.78	0
C6c	PVUL-LPAR	GLC-INU	0	0	0
C7c	LBRE-BTHE	GLC-INU	0	0	0
C8c	LBRE-BTHE-LPAR	INU	1.14	0	0
C9c	LSYM-BADO-LPAR	INU	1.16	0	5.77
C10c	LPLA-LSYM-BADO	INU	1.22	0	1.19
C11c	PDOR-LSYM-BADO	INU	1.23	0.38	0.73
C12c	PDOR-LSYM-BADO-LPAR	INU	0	0	0
C13c	LBRE-LPAR-BTHE-LSYM	INU	0	0	0

Three rounds of simulations are shown (a, b, c). Models and abbreviations used are indicated in Supplementary Table 1, and inulin (INU) or glucose (GLC) were used in silico.

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