Fig. 6: Bioinformatic analysis of the B. breve lw01 genome and its Bsh gene. | npj Biofilms and Microbiomes

Fig. 6: Bioinformatic analysis of the B. breve lw01 genome and its Bsh gene.

From: Deconjugating taurocholic acid with Bifidobacterium to mitigate obesity-driven cancer progression by restoring CD8+ T-cell infiltration

Fig. 6

A Circle map of the B. breve lw01 genome: genome sequence (ring 1), coding DNA sequences on the positive and negative strands (rings 2 and 3), RNA genes, ncRNA regions, CRISPR, Ori C (ring 4), GC content (ring 5), and GC skew (ring 6) are shown. B KEGG annotation and enrichment analysis. C GO annotation and enrichment analysis. D Schematic of the Bsh sequence construction and location. E Neighbour-joining phylogenetic tree of all genes annotated as bile salt hydrolase (choloylglycine hydrolase)-encoding genes (Bsh) in the Bifidobacterium species recorded in the NCBI database. F Predicted structures of B. breve lw01 BSH (upper panel) and consensus phylotype 4 BSH (lower panel). G Amino acid alignment of B. breve lw01 BSH and phylotype 4 BSH; the headers in grey represent the spatial variation per column, and the coloured boxes represent the structural similarity between regions. BSH bile salt hydrolase, KEGG Kyoto Encyclopedia of Genes and Genomes, GO Gene Ontology.

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