Fig. 5: Virulence gene distribution across L1 species.

A A heatmap illustrating the distribution of known ‘F. nucleatum’ virulence factors across L1 species. Gene/operon copy numbers are visualised by colour gradience. B The eut operon is conserved in L1 species. Representative gene clusters are drawn for the strains SB010 for F. animalis (reference), KCOM 1261 for F. pseudoperiodonticum, ChDC F174 for F. hwasookii, OH4460_COT-188 for F. canifelinum, ATCC 25586 for F. nucleatum, THCT14A3 for F. vincentii and THCT15E1 for F. polymorphum. Genes with no counterparts in the reference operon are marked in grey. C The eut operons exist in various L1 species. Gene clusters are drawn based on strains SB010 for F. animalis (reference), OH4460_COT-188 for F. canifelinum, THCT15E1 for F. polymorphum, and ChDC F174 for F. hwasookii. Nucleotide identities to the reference operon are given.