Table 1 Associations between TP53 rs1800371 and breast cancer risk in African-American women in the AMBER, ROOT, and AABC Consortia
From: A functionally significant SNP in TP53 and breast cancer risk in African-American women
TP53 rs1800371 | Controls | All cases | p-value | ER+cases | p-value | ER-cases | p-value |
|---|---|---|---|---|---|---|---|
All women | |||||||
AMBER | |||||||
N | 3698 | 3130 | — | 1674 | — | 963 | — |
MAF | 0.014 | 0.016 | — | 0.015 | — | 0.016 | — |
OR (95% CI)* | — | 1.17 (0.84–1.62) | 0.34 | 1.08 (0.73–1.60) | 0.70 | 1.18 (0.73–1.92) | 0.49 |
ROOT | |||||||
N | 2029 | 1657 | — | 403 | — | 374 | — |
MAF | 0.011 | 0.012 | — | 0.017 | — | 0.013 | — |
OR (95% CI)** | — | 1.10 (0.58–2.08) | 0.78 | 2.31 (0.91–5.86) | 0.077 | 1.04 (0.35–3.07) | 0.95 |
AABC | |||||||
N | 1917 | 2120 | — | 1117 | — | 591 | — |
MAF | 0.014 | 0.014 | — | 0.013 | — | 0.014 | — |
OR (95% CI) | — | 1.08 (0.71–1.65) | 0.70 | 1.25 (0.74–2.12) | 0.41 | 1.00 (0.53–1.86) | 0.99 |
Premenopausal women | |||||||
AMBER | |||||||
N | 1490 | 1218 | — | 631 | — | 398 | — |
MAF | 0.013 | 0.019 | — | 0.016 | — | 0.019 | — |
OR (95% CI)* | — | 1.79 (1.07–2.99) | 0.027 | 1.52 (0.80–2.87) | 0.20 | 1.98 (0.95–4.11) | 0.07 |
ROOT | |||||||
N | 898 | 724 | — | 146 | — | 169 | — |
MAF | 0.010 | 0.012 | — | 0.015 | — | 0.013 | — |
OR (95% CI)** | — | 1.39 (0.51–3.78) | 0.52 | 1.84 (0.35–9.77) | 0.48 | 1.17 (0.22–6.28) | 0.86 |
Meta-analysis of AMBER and ROOT | |||||||
Per A allele OR (95% CI)*** | — | 1.72 (1.08–2.76) | — | 1.64 (0.88–3.05) | — | 1.72 (0.87–3.40) | — |
p-value for testing association | — | 0.023 | — | 0.12 | — | 0.12 | — |
p-value for testing heterogeneity | — | 0.89 | — | 0.96 | — | 0.95 | — |
