Table 1 Epidemiological measures of the frequency of interval breast cancers in population mammography screening
Study first author | Screening settinga; age-group screened | Cancer detection rate per 10,000 screens | Interval cancer rate per 10,000 screens reported for all screens: overall or by inter-screen interval | Interval cancer rate per 10,000 screens where reported separately for initial and repeat screens | Proportional interval cancer rateb | Percentage of cancers (from all BCs in screened women) that are interval cancersc |
|---|---|---|---|---|---|---|
Weber13 | Southern screening region of Dutch program (2000–11), 302,699 film-screen and 115,047 digital mammograms; 50–75 years | Digital 69 Film-screen 52 | Digital 17 Film-screen 20 | – | – | Digital 19.4% Film-screen 28% |
O'Brien4 | Irish population breast screening program (2000–07); 50–64 years | 53.6 (initial 66.9; repeat 41.4) | Overall 19.2 year 1: 5.8 year 2: 13.4 | Initial 19.6 Repeat 18.9 | 40% | 26% |
Henderson21 | Breast Cancer Surveillance Consortium, USA (2003–11), 3,021,515 mammograms (40.3% digital, 59.7% film); 40–89 years | Digital 44.7 Film-screen 44.2 | 12-month interval: Digital 7.3 Film-screen 7.9 | – | – | 14.7% (annual screening) |
Carbonaro15 | Milan, Italy, population breast screening program (2001–06); 49–69 years | 55.2 | Overall 17.0 | – | 29.0% (initial 19%; repeat 39%) | 23.3% |
Renart-Vicens26 | Girona, Spain, Health Region screening program (2000–06), 50–69 years | 49.0 | Overall 7.0 | – | Range 9.3 to 47.7% | 13% |
Fong18 | Breast Test Wales screening program (1998–2001); 50–64 years | 51.0 | Overall 34.8 | – | – | 38% (3-yearly screening) |
Heidinger20 | German mammography screening program/North Rhine-Westphalia cancer registry (2005–08), 50–69 years | [study of initial screening round] 81.0 | Overall 23.2 Year 1: 7.4 Year 2: 15.7 | (all data are for initial screens) | Year 1: 27% Year 2: 58% | 22% |
Bennett16 | National Health Service breast screening programme England, Wales, and Northern Ireland (1997–2003); 50–64 years | 60.4 | Overall 29.1 year 1: 5.5 year 2: 11.3 year 3: 12.2 | – | – | 32.5% (3-yearly screening) |
Tornberg28 | Navarra, Spain, population screening (1990–96); 45–65 years | 41.5 (initial 63.0; repeat 31.3) | Overall 8.4d year 1: 2.1d year 2: 6.3d | Initial 7.2e Repeat 9.0e | 25.9%d (initial 22%; repeat 28%)e | 17%d |
Seigneurin27 | Isere, France, population screening – time frames are for change from 1-view to 2-view mammography: (2002–04) 50–69 years; (1994–99) 50–69 years | 2002–04: 70.4 1994–99: 53.0 | 2002–04: Overall 15.3 year 1: 3.2 1994–99: Overall 23.9 year 1: 6.8 | 2002–04: Initial 17.3 Repeat 13.6 1994–99: Initial 24.7 Repeat 23.2 | 2002–04: 31.2%d 1994–99: 48.7%d | 2002–04: 17.8% 1994–99: 31% |
Bordas17 | Norrbotten, Sweden, population screening program (1989–2002); 40–74 years | 29.4 | Overall 10.7 year 1: 5.1 year 2: 5.6 | – | 33.4%d | 26.6% |
Tornberg28 | Florence, Italy, population screening program (1990–94); 50–69 years | 77.1 (initial 91.0; repeat 40.1) | Overall 15.3 year 1: 3.9 year 2: 11.4 | Initial 13.3e Repeat 21.0e | 34.4%d (initial 30%; repeat 47%)e | 17%d |
Tornberg28 | Turin, Italy, population screening program (1992–96); 50–59 years | 78.7 (initial 86.1; repeat 62.6) | Overall 15.5 year 1: 5.5 year 2: 10.0 | Initial 14.0e Repeat 19.2e | 35.0%d (initial 35%; repeat 47%)e | 16%d |
Fracheboud19 | Netherlands population screening program (1990–93); 50–69 years | 57.3 (initial 65.7, repeat 34.6) | Overall 18.2d year 1: 6.1d year 2: 12.1d | Initial 18.1 Repeat 18.6 | 39.3%d | 24%d |
Törnberg28 | Marseille, France, population screening (1993–98); 50–69 years | 46.7 (initial 46.5; repeat 47.3) | Overall 17.4 year 1: 5.4 year 2: 12.1 | Initial 17.3e Repeat 18.1e | 43.3%d (initial 43%; repeat 45%)e | 27%d |
Törnberg28 | Strasbourg, France, population screening (1989–97); 50–65 years | 42.7 (initial 51.9; repeat 37.2) | Overall 21.3 year 1: 6.9 year 2: 14.4 | Initial 20.5e Repeat 22.0e | 47.2%d (initial 45%; repeat 49%)e | 33%d |
Törnberg28 | Four counties, Norway (1996–97); 50–69 years | 67.2 | Overall 19.5 year 1: 4.5 year 2: 15.0 | Initial 16.4e Repeat n/a | 48.7%d (initial 41%; repeat n/a)e | 22%d |
Törnberg28 | Pirkanmaa, Finland (1988–99); 50–69 years | 36.3 (initial 41.6; repeat 32.3) | Overall 17.4 year 1: 6.5 year 2: 11.0 | – | 66.4%d | 32%d |
Lynge24 | Copenhagen, Denmark (1991–93 [initial] and 1993–95 [repeat]); 50–69 years | (Initial 118.6; repeat 62.5)b | – | Initial 17.3e Repeat 20.5e | (Initial 34%; repeat 40%)e | Initial 13% Repeat 25% |
Njor25 | Funen, Denmark (1993–95 [initial] and 1996–97 [repeat]); 50–69 years | (Initial 95.9; repeat 52.1)b | – | Initial 21.2e Repeat 24.2e | (Initial 43%; repeat 47%)e | Initial 18% Repeat 32% |
Törnberg28 | Stockholm, Sweden, screening program (1989–97); 50–69 years | 47.6 (initial 58.9; repeat 39.8) | Overall 21.1 year 1: 7.3 year 2: 13.8 | Initial 20.4e Repeat 21.7e | (Initial 40%; repeat 46%)e | Initial 26% Repeat 35% |
Hofvind22 | Norwegian breast cancer screening program (1996–2005 [initial] and 1988–2005 [repeat]); 50–69 years | 56.4 (initial 64.8; repeat 49.2) | 18.2 | Initial 18.3 Repeat 18.2 | 51%e | Initial 22% Repeat 27% |
Kellen23 | Belgian province of Limburg population screening program (1996–2001); 50–69 years | 101 (included prevalent screening) | Overall 49.3 (for 3-year interval) | – | Year 1: 21.7% Year 2: 11.3% | 36.6% (biennial program but included 3-year interval BC data) |
Vettorazzi29 | Screening program in local health units of Veneto Region, Italy (1999–2002); 50–69 years | [initial screening round] 72.0e | – | (all data are for initial screens) 16.3e | 29% (year 1: 21%;year 2: 46%) | 18% |
